This book on nanoformulation of cancer drugs provides a naotechnology based practical approach towards solving the current problems of uncontrollable drug delivery and adverse effects associated with systemic chemotherapy. The research is applied on common chemotherapy drugs like ‘Paclitaxel'' and ‘Tamoxifen'' but not limited to therapeutic agents, as nanoformulation of ‘Gadolinium'', a MRI contrast agent is also described here. This work was performed at the nanotechnology labs of LA Tech University''s well known "Institute for Micromanufacturing" (IFM),USA, under the guidance of one of the pioneers in this field, Dr. Yuri M. Lvov. Part of this work was featured as the cover story in 7th issue of the international pharmaceutical magazine "Pharma Focus Asia" as "R&D @ NANO LEVEL" in 2008 and also published in peer reviewed journals including the well celebrated drug delivery medical journal "Journal of Controlled Release." This research counted towards a US Patent application and received national level funding. In the April 2009 issue of IFM Newsletter, the author has been quoted as "A person who is a brilliant professional both in engineering and medicine."
Kidney stone disease is becoming one of the commonest disease in all over the world. The pain due to the disease is worst than labour pain.Earlier only males were susceptible, now a days women's also suffering from stone disease. The main reason behind this is changes in life style and food habits. The peoples are less aware about the disease, so their is a need to create awareness among stone patients. This book contains in detail information on all the aspects of stone disease. I think it will be useful for stone patients.
Purine nucleosides have significant importance and pivotal effects in medicinal chemistry. As part of our program of research on the synthesis of purine analogs and other antimetabolites. We have previously reported several new approaches for the synthesis of mercaptopurine analogs and their thioglycosides, these ring systems are interesting because they are purine analogs and as such they have useful properties as antimetabolites in purine biochemical reactions. The aim of this book was to address the use of recent reported purine nucleosides in drug discovery and development. Following the enormous developments in the novel synthetic strategies of the purine nucleosides, we surveyed the most recent and up-to-date synthetic approaches of the purine nucleosides that reflect its comprehensive importance in the different fields. Consequently, the new insights of a broad array of novel compounds have been demonstrated. The biological evaluation of the novel synthesized compounds were emphasized. Their synthetic procedures were also elaborated.
Wounded amputees are faced with myriad issues involving mutilation, pain, multiple surgeries, body image issues, depression, anxiety, and post traumatic stress disorder symptoms. All are common and must be addressed rapidly with ongoing counseling and pharmacologic management and along period of rehabilitation.The aim of this study was to investigate the effect of a designed training-counseling program on psychological stress among Gaza War amputees in Gaza Governorates. Quasi-experimental design (pre-test/post-test) was used in this study.The study was conducted on the 24 subjects who have the highest stress level scores. The training counseling program was designed on Albert Ellis theory for rational emotive behavior therapy. Results revealed that the designed training counseling program was having an effective impact on reducing psychological stress level among Gaza war amputees. The study concluded that Gaza war amputees were exposed to a higher stress level that could negatively affect all their life aspects.However,the training counseling program showed a positive impact on reducing their psychological stress level and promoting their abilities to function productively.
Consensus, or the level of agreement among the senior management team of a firm, had been the subject of interest in strategic management literature. Prior studies seemed to suggest that a higher level of agreement among the executive team would be associated with enhanced firm performance. This study extended prior researches on consensus by finding out if senior managers’ consensus on quality improvement decision processes (which pertained to management procedures for selecting and implementing an improvement theme or project) will be positively related to firm quality performance. In addition, this study attempted to find out if the firm’s emphasis on differentiation strategy vis-a-vis cost leadership strategy will moderate the relationship between consensus on quality improvement and firm quality performance. The study also determined if perceptions on market uncertainty will moderate the relationship between consensus on quality improvement and the quality performance of firms. Primary data were gathered through a survey of 45 Philippine firms taken as sample. Statistical analyses used multiple regression to test the hypothesized relationships among the variables studied.
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents.Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects.Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.
Quality of life of breast cancer patients is a critical approach to the conceptualization and measurement of quality of life in breast cancer patients. The aim of this book is to assist breast cancer patients, their families and public to understand Quality of Life of breast cancer patients. It contains a comprehensive view of quality of life among breast cancer patients. This book describes what we mean by quality of life of breast cancer. It explores ideas about quality of life among real Malaysian breast cancer patients and describes their experiences through their own personal experiences in everyday life.
Coumarins are naturally occurring benzopyrene derivatives have been identified from natural sources, especially green plants. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. The coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their cytotoxic effects were most extensively examined. Moreover coumarins have simple structure with least toxicity made them first choice to select for biological screening. The research work was designed based on the research findings reported in various literatures supporting the anti oxidant,anti cancer and antimicrotubular activity of courmarin compounds derived from substitution at different position of coumarin scaffold. From literatures, it showed that coumarins with substitution at 4th and 7th position with various substituents like –OH, -CH3, -COOH, Pyridine showed profound biological activity. Moreover coumarins have simple structure with least toxicity made them first choice to select for biological screening.
Breast cancer is a complex disease with many factors that can contribute to its development. As such, informative biomarkers are required to accurately and comprehensively characterize breast cancer so that patient management is both informed and optimal. Current breast cancer biomarkers, although useful, have limitations and are sometimes unable to classify all breast cancer patients. Therefore, new classes of biomarkers and detection tools are needed. A possible complement to existing biomarkers is the aberrant DNA methylation of miRNA promoters in breast cancer. This book will take the reader on a journey from discovering a novel biomarker to developing a new technology for detecting this potential biomarker in clinical practice. The genetics/biotechnology interdisciplinary combination may appeal to readers majoring in either field and to anyone interested in interdisciplinary research.