Pancreatic Cancer – A Patient and His Doctor Balance Hope and Truth
Cancer is a disease of uncontrolled cell growth and proliferation that is predicted to directly affect 1 in 3 Canadians. Standard chemotherapy that targets DNA or its replicative machinery effectively eradicates cancer cells, but also causes non-specific toxicity to healthy cells. Pancratistatin, a natural alkaloid isolated from Hymenocallis littoralis, was found to selectively induce apoptosis (programmed cell death) in many types of human cancer cells, with an insignificant effect on healthy non-cancerous cells. Major findings presented in this work are: the selectivity and efficacy of pancratistatin and synthetic derivatives on patient-obtained and commercially available leukemia; the potent effect of pancratistatin on human colon and prostate cancer cells in vitro and in vivo; and the unique mechanism of action of pancratistatin. In summary, pancratistatin is a natural anti-cancer compound that selectively targets cancer cell mitochondria to induce apoptosis and significantly reduces growth of human tumor xenografts.
About one-sixth of patient encounters are perceived by clinicians as involving "difficult patients. These patients often require special attention because their care is very complex and have ethical pitfalls. There are fewer studies on the difficult patient encounter in physiotherapy practice as opposed to other health professions such as medicine and nursing. However, behavioural problems of patients and patient satisfactions are some of the areas physiotherapists have found very difficult. This book presents a study on physiotherapists’ perception and strategies for the management of the difficult patient.
Apoptosis, a major form of cell death, is characterized by several unique features, including cell shrinkage, nuclear collapse, membrane blebbing, and internucleosomal DNA cleavage. Defects in apoptosis facilitate tumor progression, by rendering cancer cells resistant to death mechanisms relevant to metastasis, growth factor deprivation and chemotherapy. To date, the cervical carcinoma is the second most common cancer in women, and is one of the major causes of death among women in the world. Chondrosarcoma is a malignant primary bone tumor and the third most common primary malignancy of bone after myeloma and osteosarcoma. Thus, we chose human cervical cancer cells (Hela) and human chondrosarcoma cells (SW1353) for the study. Marine-derived fungi have proved to be a promising source of bioactive metabolites and a growing number of marine fungi have been reported to produce bioactive secondary metabolites. Several fungal metabolites isolated from Aspergillus sp. It has been shown to exert antitumor, antiinflammator, induced cytotoxicity and antibacterial activity.
This book has discussed some stochastic models on cancer cell growth with Bi-variate stochastic processes. The pathophysiology of cancer growth was modeled with postulates of Poisson processes. In the first phase, the mathematical relations for various statistical measures like expected number, variances of both normal and mutant cells were derived for normal and mutant cells. The second phase deals with extension of proposed model to study the tumor behaviour during drug administration and during drug vacation as a part of cancer treatment with chemotherapy. Sensitivity analysis of the model is carried out with suitable simulated numerical data. Stochastic model for cancer growth as a result of spontaneous mutation and proliferation of cells during drug vacation and during chemotherapy were developed. The model is extended for two stage mutant cell growth. The third phase of the study has formulated two stochastic programming problems for optimal drug administration in drug presence and absence, for calculating the drug effectiveness during chemotherapy. Health care industry may make use of these studies for optimal management of disease
This book examines how patient empowerment based on Internet information has impact on health care processes and patient – physician relationship. The process of empowerment is analyzed in three main steps; searching and obtaining information; sharing and discussing obtained information with providers; and involving decision making process. Study domain covers with breast cancer patients continuing their treatment in hospitals. In-depth interview methodology has been employed. Interviews are conducted in two settings: one is a university hospital; other is a state hospital of Ministry of Health. Sample size was 20 patients and 6 doctors. As result of study we observed that most of the breast cancer patients have low level of empowerment. This is mainly caused by perception of cancer and high level of anxiety of patients.
Following the international success of Your Life in Your Hands, the groundbreaking book on breast cancer, Professor Jane Plant explains how her diet and lifestyle plan can be used to combat prostate cancer. This revised and updated edition includes new information to help those with other types of cancer, such as colorectal cancer and testicular cancer. In this groundbreaking book, Professor Plant illuminates the relationship between cancer and diet. The book explains the science behind the 'no dairy' diet and then gives useful advice on diet and lifestyle to maximise your health and avoid contracting cancer. For sufferers, their families and anyone who is concerned about the risk of cancer, this book is essential.
Testicular cancer presents real challenges due to its unique descriptive epidemiology and relatively unknown etiology. The social and epidemiological importance of testicular tumors has grown with the rapid increase of its incidence in the population of younger males between 20 and 40 years, that results in long term disability and/or the invalidization of the fertile male population. Survival for testicular cancer patients is better than for all other malignant diseases, but significant differences worldwide have been documented. Early diagnosis is determined by the biologic features of the tumor, patients’ knowledge about the disease, and the availability of general practitioners and specialists to analyze initial symptoms to determine a correct diagnosis and begin adequate treatment. Surgical exploration and orchiectomy is consider as definitive diagnostic procedure and the first step of the treatment. The individual treatment strategy is based on the TNM classification and the classification of the IGCCCG based on prognostic factors. The patient must be well informed about these modalities, their acute and late toxicities and overall outcome.
The study presented herein was performed in partial fulfillment of the requirement for the degree of Master of Science (Anatomy)of the All India Institute of Medical Sciences, New Delhi, in 1985. I wish to express my gratitude to my teacher, Dr. (Mrs) Kiran Kucheria, for her guidance and encouragement. This work is dedicated to the patients suffering with the dreadful disease of cancer, who have willingly given their blood, without whose cooperation this work would not have been possible.
Fight cancer from the inside out Cancer treatments such as surgery, chemotherapy, and radiation can be as hard on the body as the disease itself, and detailed nutritional advice is usually not part of the program. Yet eating the right foods can actually help lessen the strength of some of the most powerful symptoms of cancer and the side effects of treatment, allowing the patient to better fight the disease. Now, Cancer Nutrition & Recipes For Dummies is your trusted, informative guide to fighting cancer from the inside out. Designed for cancer patients and their families, Cancer Nutrition & Recipes For Dummies focuses on foods best tolerated during--and that can ease side effects of--cancer treatment. It also offers advice for menu planning, nutritional analysis, diabetic exchanges, and much more. Serves as a guide for cancer nutrition before, during, and after treatment Gives you a wealth of easy, immediate steps to speed up the healing process through diet Offers advice on treatment as well as solutions to common side effects like dehydration, fatigue, and nausea Enables cancer patients to put their strongest foot forward when starting treatment Cancer Nutrition & Recipes For Dummies targets those dealing with cancer and the loved ones who take care of them, aiding both parties in alleviating some of the side effects of the cancer treatment through change in diet.
Chemotherapy induced nausea and vomiting (CINV) is a serious distress for cancer patients, who have to receive chemotherapy for their treatment. Ondansetron HCl is an effective antiemetic drug which is used to prevent CINV. But this drug is commercially available in the form of tablet and injection, which causes its hepatic “first pass” metabolism or rapid clearance from the body, respectively. Hence, the need to formulate such a dosage form of this drug that will not only enhance its bioavailability but also provide adequate patient compliance. This book focuses on development and in vitro evaluation of a mucoadhesive buccal film of ondansetron HCl which will deliver the drug in a sustained manner via buccal mucosa and help to maintain effective blood level of the drug for a prolonged period.
Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative.The pain experience and subjective assessment of pain varies greatly among people.In psychological studies, behavioral measures are gathered by asking the patient or subject to rate their feelings based on a specific scale. This approach is useful in the clinical setting to assess a patient?s perceived amount of pain. However, behavioral measures do not point to the specific brain areas involved in cognitive or affective phenomenon during distress or injury. Hence, several researchers have taken the progressive step of combining behavioral measures with the spatio-temporal aspects of brain activity available through neuroimaging. Near Infra-Red Spectroscopy (NIRS) is a promising technology as it provides several advantages such as non-invasiveness, inherently non-ionizing radiation, patient-friendliness, portability and low cost electronics. The goal of this dissertation work is to develop novel methods to quantify neural correlates between pain perception and NIRS measurements acquired from the prefrontal cortical areas.
Epigenetic is one the most important and distinct molecular pathway in colorectal cancer.The epigenetic pathway affect the level of expression of multiple cancer candidate genes essential for cell cycle control, DNA repair, and many others actions within the colon mucosa. Therefore, besides mutations, epigenetic changes including the promoters’ methylation of a set of cancer candidate genes (CAN genes) are associated with the CRC progression. Transcriptional silencing by the hypermethylation of CpG islands is an early event in tumor progression and is considered as a methylator phenotype.
Oral cancer is one of the most prevalent cancers of the world. It is among the top ten reasons to cause death. Oral cancer ranks one among all the cancers caused among men, which represents 4% of all deaths among men. In women it stands third among all cancers and represent 2% of all deaths. Oral cancer due to its location in the most accessible part of the body, i.e. the mouth it can be detected in the early stages. However, because of lack of symptoms, especially pain, it is neglected and often recognized at the advanced stage thus a proper medical care is not reached in the initial stage. Hence it is important for all the health professionals to equip themselves with adequate knowledge to detect this disease at early stage.